Traduzione in corso

Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

Sudharshan Eathiraj, Rocio Palma, Erika Volckova, Marscha Hirschi, Dennis S. France, Mark A. Ashwell and Thomas C. K. Chan


J Biol Chem. 2011 Jun 10; 286(23): 20666–20676.

doi:  10.1074/jbc.M110.213801


Parole chiave:Drug Design, Kinetics, Protein Phosphorylation, Protein Structure, Receptor Tyrosine Kinase, X-ray Crystallography, c-Met, Kinase Autoinhibition, Noncompetitive, Small Molecule Protein Inhibitor